Alkaloids from the Tunicate Polycarpa Aurata from Chuuk Atoll

Abas, Sayed A.; Hossain, M. Bilayet; van der Helm, Dick; Schmitz, Francis J.; Laney, Maureen; Cabuslay, Ronnel; Schatzman, Randall C. (1996-01-01). "Alkaloids from the Tunicate Polycarpa Aurata from Chuuk Atoll". Journal of Organic Chemistry. 61 (8): 2709–2712. doi:10.1021/jo960040e. ISSN 1520-6904.

Abstract: Two new alkaloids, polycarpine (1) and N,N-didesmethylgrossularine-1 (4), have been isolated from extracts of the ascidian Polycarpa aurata collected in Chuuk, Federated States of Micronesia. Three degradation products of 1 were also isolated. The structures of 1, 2, and 4 were determined by X-ray crystallography. The dimeric disulfide 1 inhibited the enzyme inosine monophosphate dehydrogenase, but the inhibition could be reversed by addition of excess dithiothreitol suggesting that 1 reacts with sulfhydryl groups on the enzyme.

Extra details:

PMID: https://pubmed.ncbi.nlm.nih.gov/11667906
MAG: 1970916557
OpenAlex: W1970916557
CorpusID: 30661329
QID: Q45932911
TLDR: Two new alkaloids, polycarpine and N,N-didesmethylgrossularine-1, have been isolated from extracts of the ascidian Polycarpa aurata collected in Chuuk, Federated States of Micronesia by X-ray crystallography.