Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios Erectus

Kwon, Oh-Seok; Kim, Donghwa; Kim, Chang-Kwon; Sun, Jeongyoon; Sim, Chung J.; Oh, Dong-Chan; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon (2020-05-13). "Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios Erectus". Marine Drugs. 18 (5): 253–271. doi:10.3390/md18050253. ISSN 1660-3397.

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Abstract: Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (1–8), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle.

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MAG: 3024910900
OpenAlex: W3024910900